Simulation of Multivariate Normal Rectangle Probabilities and Their Derivatives: Theoretical and Computational Results An extensive literature in econometrics and in numerical analysis has considered the problem of evaluating the multivariate normal integral over a rectangle. A leading case of such an integral is the negative orthant probability. The problem is computationally difficult except in very special cases. The multinomial probit (MNP) model used in econometrics and biometrics has cell probabilities that are negative orthant probabilities, with means and covariances depending on unknown parameters (and, in general, on covariates). Estimation of this model requires, for each trial parameter vector and each observation in a sample, evaluation of the probability and its derivatives with respect to mean and covariance parameters. This paper surveys Monte Carlo techniques that have been developed for approximations of the probability and its linear and logarithmic derivatives, that limit computation while possessing properties that facilitate their use in iterative calculations for statistical inference: the Crude Frequency Simulator (CFS), Normal Importance Sampling (NIS), a Kernel-Smoothed Frequency Simulator (KFS). Stern's Decomposition Simulator (SDS), the Geweke-Hajivassiliou-Keane Simulator (GHK), a Parabolic Cylinder Function Simulator (PCF), Deak's Chi-squared Simulator (DCS), an Acceptance/Rejection Simulator (ARS), the Gibbs Sampler Simulator (GSS), a Sequentially Unbiased Simulator (SUS), and an Approximately Unbiased Simulator (AUS). The authors also discuss Gauss and FORTRAN implementations of these algorithms and present our computational experience with them. The authors find that GHK is overall the most reliable method.